ANTONY M. DEAN
Department of Ecology, Evolution & Behavior
PhD, Washington University St. Louis, 1987
Molecular evolution, enzymology; experiments with bacterial enzymes known collectively as isopropylmalate dehydrogenase (IDH).
Antony Dean is interested in discerning the effects of natural selection on evolution at the molecular level. The approach used by the Dean lab places a strong emphasis on the relations between protein structure and protein function in an effort to understand the mechanistic basis of natural selection. Specifically, the Dean lab utilizes two metabolic systems in Escherichia coli as models of molecular evolution: the lactose operon and the isocitrate dehydrogenase.