Leveraging a large microbial strain collection for natural products studies
Scripps Florida houses one of the world’s largest actinobacterial strain collections, totaling >125,00 strains. These strains were isolated over the last eight decades and from 69 different countries, spanning at least 88 different genera. A natural products library (NPL) has also been constructed, consisting of 46,031 crude extracts, 28,739 partially purified fractions, and 650 pure NPs, which were made from 14,635 actinobacterial strains.
Current effort has been focused on sequencing the strain collection to establish the Natural Products Genomics Resource Center (NPGRC) for the broad scientific community.
Selected studies will be presented to highlight how to leverage the strain collection, the NPL, the NPGRC database, and the associated enabling technologies to transform the current paradigms of microbial natural product discovery and how to exploit this unique natural products resource to target emerging biology and accelerate drug discovery.
THURSDAY I APR. 28 I 3:30-4:30 PM CST I HYBRID SEMINAR