BTI publications: May - November 2025

Publications by BTI faculty
November 18, 2025

Ajayi, O. B., Arnold, W. A., Wright, N., Guest, J. S., & Novak, P. J. (2025). In anaerobic reactors the microbial community structure depends on feed type, with no "keystone" species tied to COD removal. Front Microbiol, 16, 1583463. https://doi.org/10.3389/fmicb.2025.1583463

Badger, J., Alirigia, R., Ameli, I., Bajer, P., Bartodziej, B., Dalgleish, V.,…Smanski, M. J. (2025). Coproducing a Technology Readiness Level framework for non-persistent genetic biocontrol of aquatic invasive species. J Environ Manage, 391, 126189. https://doi.org/10.1016/j.jenvman.2025.126189

Barney, B. M., Camur, B. B., Stolp, L. J., Mancipe, N. C., & Dietz, B. R. (2025). Azotobacter vinelandii as a Nitrogen-Negative Chassis for Bio-Oil and Bio-Wax Production of Heterologous and Native Lipids. Microbiologyopen, 14(4), e70047. https://doi.org/10.1002/mbo3.70047

Barney, B. M., & Dietz, B. R. (2025). Enhanced Urea Production in the Diazotroph Azotobacter vinelandii as a Means of Stable Nitrogen Biofertiliser Production. Microb Biotechnol, 18(7), e70187. https://doi.org/10.1111/1751-7915.70187

Billmann, M., Costanzo, M., Zhang, X., Hassan, A. Z., Rahman, M., Brown, K. R.,…Boone, C. (2025). A global genetic interaction map of a human cell reveals conserved principles of genetic networks. bioRxiv. https://doi.org/10.1101/2025.06.30.662193

Bisesi, A. T., Carlson, R. P., Cotner, L., & Harcombe, W. R. (2025). Metabolic remodeling of microorganisms by mobile genetic elements alters mutualistic community composition. mSystems, 10(9), e0014425. https://doi.org/10.1128/msystems.00144-25

Bosma, J. S., Noireaux, V., & Bowden, S. D. (2025a). A Gifsy prophage-encoded protein confers broad phage resistance in. Appl Environ Microbiol, e0138425. https://doi.org/10.1128/aem.01384-25

Bryson, S., Sisson, Z., Nelson, B., Grove, J., Reister, E., Liachko, I.,…Khoruts, A. (2025). Use of proximity ligation shotgun metagenomics to investigate the dynamics of plasmids and bacteriophages in the gut microbiome following fecal microbiota transplantation. Gut Microbes, 17(1), 2559019. https://doi.org/10.1080/19490976.2025.2559019

Byrd, N., Egan Morriss, C., Parker, J., Cai, R., Nunn, E. J., van Wonderen, J. H.,…Lloyd, J. R. (2025). Hydrogenase Mediated Biosynthesis of Catalytically Active Cu Nanoparticles. Small, 21(35), e2500210. https://doi.org/10.1002/smll.202500210

Cecil, R. E., Ornelas, E., Phan, A., Medina-Chavez, N. O., Travisano, M., & Yoder-Himes, D. R. (2025). Long-term culturing of. Appl Environ Microbiol, e0097525. https://doi.org/10.1128/aem.00975-25

Cohen, H., Angulski, A. B. B., Quick, J. D., Kuebler, T. S., Thompson, B. R., Bauer, J.,…Metzger, J. M. (2025). Synthetic bottlebrush block copolymer prevents disease onset in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A, 122(42), e2513599122. https://doi.org/10.1073/pnas.2513599122

Comba, I. Y., Hoops, S., Till, L., Vangay, P. J., Johnson, S., Xiao, Y.,…Kashyap, P. C. (2025). Shared environments can facilitate microbial transmission and alter metabolic outcomes. Gut Microbes, 17(1), 2562345. https://doi.org/10.1080/19490976.2025.2562345

Davisson, J. A., Alejo, J. L., Blank, M., Kalb, E. M., Prasad, A., Knudson, I. J.,…Adamala, K. P. (2025). High Yield, Low Magnesium Flexizyme Reactions in a Water-Ice Eutectic Phase. Biochemistry, 64(17), 3681-3687. https://doi.org/10.1021/acs.biochem.5c00371

Dietz, M., Gates, T. J., Sikdar, R., Subramanian, S., Elias, M. H., & Staley, C. (2025). Impeding Quorum Sensing Among the Intestinal Microbiota Impacts the Metastatic Rate of Colorectal Cancer. Cancer Med, 14(12), e71009. https://doi.org/10.1002/cam4.71009

Dougherty, E. N., Murray, M. F., Laam, L. A., Kerver, G. A., Stanley, T. B., Koball, A. M.,…Engel, S. G. (2025). Boredom and stress as momentary predictors of loss of control eating after metabolic and bariatric surgery: a longitudinal investigation. Surg Obes Relat Dis. https://doi.org/10.1016/j.soard.2025.09.008

Du, M., Chaćon, J. M., Park, H., Putnam, C., Gedeon, T., Harcombe, W. R., & Carlson, R. P. (2025). Cellular Economics of Exchanged Metabolites Alter Ratios of Microbial Trading Partners in a Predictable Manner. ACS Synth Biol. https://doi.org/10.1021/acssynbio.5c00265

Du, Z., Dorner, M., & Behrens, S. (2025). Single-Cell Profiling of Compositional and Functional Shifts in the Activated Sludge Microbiome during Wastewater Treatment using Flow Cytometric Fingerprinting. Environ Sci Technol, 59(44), 23905-23915. https://doi.org/10.1021/acs.est.4c14260

Ebadi, M., Reddi, S., Senyshyn, L., Minot, S. S., Gooley, T., Kabage, A. J.,…Rashidi, A. (2025). Effect of fecal microbiota transplantation on gut microbiota functional profile in recipients of allogeneic hematopoietic cell transplantation. Gut Microbes, 17(1), 2551882. https://doi.org/10.1080/19490976.2025.2551882

Garcia, V. A., Eberts, P. M., Ogle, B. M., & Sarkar, C. A. (2025). Valency-affinity mapping of multivalent liposomes for tunable target cell discrimination. Drug Deliv, 32(1), 2512950. https://doi.org/10.1080/10717544.2025.2512950

Gardea-Resendez, M., Fuentes-Salgado, M., Romo-Nava, F., Prieto, M. L., Bond, D. J., Ozerdem, A.,…Frye, M. A. (2025). A Cross-Sectional Analysis of Social Determinants of Health in Bipolar Disorder: Exploring Gender-Related Differences. Bipolar Disord. https://doi.org/10.1111/bdi.70062

Gates, T. J., Wangmo, D., Bergerud, K. M. B., Keel, B. M., Staley, C., & Subramanian, S. (2025). SMAD4 mutation drives gut microbiome shifts toward tumor progression in colorectal cancer. Discov Oncol, 16(1), 1841. https://doi.org/10.1007/s12672-025-02580-6

Giaveri, S., Abil, Z., Kohyama, S., Fu, M., Levrier, A., Adamala, K.,…Westensee, I. N. (2025). Building a Synthetic Cell Together. Nat Commun, 16(1), 7488. https://doi.org/10.1038/s41467-025-62778-8

González-Delgado, A., Bonillo-Lopez, L., Johnson, M. S., Knödlseder, N., Ko, C. C., Lekbach, Y.,…Shipman, S. L. (2025). Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering. bioRxiv. https://doi.org/10.1101/2025.06.16.660010

Greiss, F., Daube, S. S., Noireaux, V., & Bar-Ziv, R. (2025). Bacterial chromosome conformation and cell-free gene expression in synthetic 2D compartments. Nat Commun, 16(1), 10026. https://doi.org/10.1038/s41467-025-65249-2

Hawkins, C., Aldape, K., Capper, D., von Deimling, A., Giannini, C., Gilbert, M. R.,…Reifenberger, G. (2025). cIMPACT-NOW update 10: Recommendations for defining new types for central nervous system tumor classification. Brain Pathol, 35(6), e70018. https://doi.org/10.1111/bpa.70018

Heisel, T., Gonia, S., Dillon, A., Hoops, S. L., Al-Ghalith, G. A., Gohl, D.,…Gale, C. A. (2025). Gut mycobiome maturation and its determinants during early childhood: a comparison of ITS2 amplicon and shotgun metagenomic sequencing approaches. Front Microbiol, 16, 1539750. https://doi.org/10.3389/fmicb.2025.1539750

Hying, Z. T., Rushmer, A. M., Loh, C. Y., Bruger, E. L., & Bazurto, J. V. (2025). Methylobacterium extorquens PA1 utilizes multiple strategies to maintain formaldehyde homeostasis during methylotrophic growth. PLoS Genet, 21(6), e1011736. https://doi.org/10.1371/journal.pgen.1011736

Jacobson, R., Castonguay, C., & Elias, M. H. (2025). Durable formulations of quorum quenching enzymes. Sci Rep, 15(1), 27435. https://doi.org/10.1038/s41598-025-12623-1

Jiao, H., Cao, Z., Gong, L., Chang, X., Fang, C., Wang, X.,…Wei, X. (2025). Plant functional group has stronger effects on soil functions than planting density: an examination with pot experiment. Front Plant Sci, 16, 1652236. https://doi.org/10.3389/fpls.2025.1652236

Kabage, A. J., Haselhorst, P. J., & Khoruts, A. (2025). Donor-centric administration of the stool donor program is vital to its feasibility and patient safety. Gut Microbes, 17(1), 2508950. https://doi.org/10.1080/19490976.2025.2508950

Kalb, E. M., Alejo, J. L., Dias-Fields, L., Knudson, I., Davisson, J. A., Maldonado, E.,…Adamala, K. P. (2025). Purification of post-transcriptionally modified tRNAs for enhanced cell-free translation systems. bioRxiv. https://doi.org/10.1101/2025.06.10.658963

Khoruts, A. (2025). The challenges and opportunities in the expanding horizons of microbiota transplant therapies. Gut Microbes, 17(1), 2559032. https://doi.org/10.1080/19490976.2025.2559032

Kohn, J., Troester, A., Ziegert, Z., Frebault, J., Boatman, S., Martell, M.,…Gaertner, W. B. (2025). The Role of Surgical and Perioperative Factors in Shaping Gut Microbiome Recovery After Colorectal Surgery. Antibiotics (Basel), 14(9). https://doi.org/10.3390/antibiotics14090881

Kottala, H., Chen, Y., & Distefano, M. D. (2025). Profiling of C-terminal prenylated proteins using tandem mass tagging. Methods Enzymol, 719, 317-345. https://doi.org/10.1016/bs.mie.2025.06.008

Kuo, H. J., Srinivasan, P., Lin, Y. C., Lu, M., Rungkittikhun, C., Zhang, Q., & Hu, W. S. (2025). Transcriptomic functional characterization of recombinant adeno-associated virus producing cell line adapted to suspension-growth. Biotechnol Prog, 41(5), e70042. https://doi.org/10.1002/btpr.70042

Le Cornet, C., Jung, A. Y., Behrens, S., Middha, P., Truong, T., Jernström, H.,…Chang-Claude, J. (2025). Exogenous Hormones, Tumor Intrinsic Subtypes, and Breast Cancer. JAMA Netw Open, 8(7), e2519236. https://doi.org/10.1001/jamanetworkopen.2025.19236

Leak, L., Wang, Z., Joseph, A. J., Johnson, B., Chan, A. A., Decosto, C. M.,…Dixon, S. J. (2025). Tegavivint triggers TECR-dependent nonapoptotic cancer cell death. Nat Chem Biol. https://doi.org/10.1038/s41589-025-01913-4

Martell, M., Quarnstrom, C. F., Khoruts, A., Vezys, V., Staley, C., & Shmidt, E. (2025). Chronic Intestinal Inflammation and Microbial Dysbiosis Are Associated With Female Reproductive Outcomes in a Mouse Model of Inflammatory Bowel Disease. Gastro Hep Adv, 4(7), 100670. https://doi.org/10.1016/j.gastha.2025.100670

Masud, S. N., Srivastava, A., Mero, P., Echezarreta, V. S., Anderson, E., van Buren, L.,…Moffat, J. (2025). Genetic suppression features ABHD18 as a Barth syndrome therapeutic target. Nature, 645(8082), 1029-1038. https://doi.org/10.1038/s41586-025-09373-5

Mikolajczyk, B. M., Golinski, A. W., & Hackel, B. J. (2025). Enzyme-substrate co-display on yeast empowers engineering of tobacco etch virus protease activity. Protein Eng Des Sel, 38. https://doi.org/10.1093/protein/gzaf011

Miller, C. R., Huang, Y., Allan, J. N., Bhat, S. A., Bond, D., Brander, D.,…Kittai, A. S. (2025). Prognostic Implication of Karyotypic Evaluation in Patients With Richter Transformation in the Modern Era. Am J Hematol, 100(9), 1709-1713. https://doi.org/10.1002/ajh.27760

Moon, S., & Smanski, M. J. (2025). Biosynthesis of tauro-ursodeoxycholic acid (TUDCA) in Saccharomyces cerevisiae. Microb Cell Fact, 24(1), 212. https://doi.org/10.1186/s12934-025-02829-3

Motallebnejad, P., Lee, Z., One, J. L., Cichocki, F., Hu, W. S., & Azarin, S. M. (2025). Integrated ATAC-seq and RNA-seq analysis identifies key regulatory elements in NK cells activated with feeder cells and IL-2. Bioeng Transl Med, 10(3), e10747. https://doi.org/10.1002/btm2.10747

Moutsoglou, D., Blake, M., Belhasan, D. C., Peichel, G., Vang, B. M., Weir, E. K.,…Thenappan, T. (2025). Microbiota Transplant Therapy Is Safe and Feasible in Pulmonary Arterial Hypertension. JACC Basic Transl Sci, 10(9), 101347. https://doi.org/10.1016/j.jacbts.2025.101347

Natarajan, O., Gibboney, S. L., Young, M. N., Lim, S. J., Nguyen, F., Pluta, N.,…Dishaw, L. J. (2025). Prophage regulation of. Elife, 14. https://doi.org/10.7554/eLife.103107

Petre, A. M., Thieschafer, J. S., Palsuledesai, C., Cornille, K., Chang, A., Li, L., & Distefano, M. D. (2025). Metabolic Labeling with an Isoprenoid Probe Reveals APOE Allele-Specific Differences in the Prenylome. ACS Chem Biol, 20(8), 1951-1961. https://doi.org/10.1021/acschembio.5c00320

Pierce, C. T., Greenberg, L. R., Walsh, M. E., Shi, K., Magee, D. J., Aihara, H.,…Kazlauskas, R. J. (2025). Crystal structure of a seven-substitution mutant of hydroxynitrile lyase from rubber tree. Acta Crystallogr F Struct Biol Commun, 81(Pt 9), 398-405. https://doi.org/10.1107/S2053230X25007034

Rhein, J., Chipman, J. G., Beilman, G. J., Cromarty, R., Escandón, K., Anderson, J.,…Schacker, T. W. (2025). Impact of the IL-15 superagonist N-803 on lymphatic reservoirs of HIV. JCI Insight, 10(13). https://doi.org/10.1172/jci.insight.190831

Ronnander, M., Dodge, A. G., O'Neal, E., Pauls, C., Hanson, J., Christenson, J. K., & Wackett, L. P. (2025). Continuous Spectrophotometric Assay for Defluorinase and Dechlorinase Activities With α-Halocarboxylic Acids. Microb Biotechnol, 18(8), e70216. https://doi.org/10.1111/1751-7915.70216

Saqr, A., Cheng, S., Al-Kofahi, M., Staley, C., & Jacobson, P. A. (2025). Microbiome-Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement. Clin Pharmacol Ther. https://doi.org/10.1002/cpt.3740

Sato, W., Sharon, J., Cash, B., Deich, C., Gaut, N. J., Heili, J.,…Adamala, K. P. (2025). One-pot cloning and protein expression platform for genetic engineering. bioRxiv. https://doi.org/10.1101/2025.08.28.672974

Shaw, D. R., Katuri, K. P., Sapireddy, V., Douvropoulou, O., Gralnick, J. A., & Saikaly, P. E. (2025). Independently evolved extracellular electron transfer pathways in ecologically diverse Desulfobacterota. ISME J, 19(1). https://doi.org/10.1093/ismejo/wraf097

Sikdar, R., Beauclaire, M. V., Herzberg, M. C., Lima, B. P., & Elias, M. H. (2025). N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque. NPJ Biofilms Microbiomes, 11(1), 204. https://doi.org/10.1038/s41522-025-00846-z

Simon, A. T., Dodge, A. G., Bondy, J., O'Connor, M. R., Aksan, A., & Wackett, L. P. (2025). Matrix-independent screening of defluorination. mBio, 16(9), e0179825. https://doi.org/10.1128/mbio.01798-25

Simpson, H. J., & Schilling, J. S. (2025). Saprotrophic Capabilities of Neurospora crassa on Charred Plant Biomass. Environ Microbiol, 27(6), e70132. https://doi.org/10.1111/1462-2920.70132

Stewart, B. D., Bone, S. E., & Santelli, C. M. (2025). Transition Metal Recovery Using Manganese-Oxidizing Microbes and Recycled Carpet Fiber. Environ Sci Technol, 59(37), 19910-19920. https://doi.org/10.1021/acs.est.5c03810

Tao, C., Liu, T., Cui, T., Liu, J., Li, Z., Ren, Y.,…Investigators, A.-I. (2025). Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke. N Engl J Med, 393(12), 1191-1201. https://doi.org/10.1056/NEJMoa2503678

Thompson, C., Trněný, M., Morschhauser, F., Salles, G. A., Reagan, P. M., Hertzberg, M.,…Friedberg, J. W. (2025). PROs vs clinician-reported adverse events in a large clinical trial: findings from the phase 3 POLARIX study. Blood. https://doi.org/10.1182/blood.2025028848

Uttech, S. K., Ordinola-Zapata, R., Noblett, W. C., Martell, M., Lima, B., & Staley, C. (2025). Multispecies Biofilms Treated With Endodontic Sealers or Calcium Hydroxide: Antimicrobial Activity and Changes in Community Composition. Int Endod J, 58(11), 1764-1773. https://doi.org/10.1111/iej.70015

van der Pol, E., Schlatzer, T., Hoffka, G., Di Geronimo, B., Eder, J., Schweiger, A. K.,…Kourist, R. (2025). Mechanistic Elucidation and Stereochemical Consequences of Alternative Binding of Alkenyl Substrates by Engineered Arylmalonate Decarboxylase. J Am Chem Soc, 147(43), 39271-39283. https://doi.org/10.1021/jacs.5c10721

Venkatachalapathy, S., Lichtenfels, C., Wagner, C. R., & Distefano, M. D. (2025). Engineering protein prenylation: an emerging tool for selective protein modification. Biochem Soc Trans, 53(4), 1129-1149. https://doi.org/10.1042/BST20253076

Wackett, L. P. (2025a). New chemicals fuel the evolution of microbial biodegradation. Microbiol Mol Biol Rev, e0020724. https://doi.org/10.1128/mmbr.00207-24

Wackett, L. P. (2025b). PFAS Biodegradation and the Constraints of Thermodynamics. Microb Biotechnol, 18(6), e70181. https://doi.org/10.1111/1751-7915.70181

Wang, B., Babele, P. K., Crockett, M. N., Abraham, J. P., Weidenbach, S., Pfleger, B. F., & Young, J. D. (2025). Targeted metabolomics-guided rational refinement of cyanobacterial metabolism enables enhanced photosynthetic production of L-lysine. Metab Eng, 92, 136-147. https://doi.org/10.1016/j.ymben.2025.07.015

Willis, J. R., Sivaganesan, M., McMinn, B., Korajkic, A., Staley, C., & Shanks, O. C. (2025). Novel Bacteroides bacteriophage-like quantitative real-time PCR assays for human sewage pollution measurement. Environ Pollut, 383, 126806. https://doi.org/10.1016/j.envpol.2025.126806

Yu, S., Sun, X., Yu, Z., Jung, J., Ishii, S., Hayes, C. T.,…Ng, T. N. (2025). Flexible point-of-use phosphate electrochemical sensors based on electrodeposited molybdenum oxide. Mater Horiz, 12(17), 6784-6792. https://doi.org/10.1039/d5mh00692a

Zhang, Y., Peng, Z., Song, Z., & Schilling, J. S. (2025). Repeated measures of decaying wood reveal the success and influence of fungal wood endophytes. mSystems, 10(9), e0038225. https://doi.org/10.1128/msystems.00382-25